Abstracts:To fully realize the potential of photoacoustic tomography (PAT) in preclinical and clinical applications, rapid measurements and robust reconstructions are needed. Sparse-view measurements have been adopted effectively to accelerate the data acquisition. However, since the reconstruction from the ... [Biomed. Opt. Express 9, 4569-4587 (2018)]

Abstracts:The flashlamp-pumped, solid-state, pulsed, mid-infrared, holmium:YAG laser (λ = 2120 nm) has been the clinical gold standard laser for lithotripsy for over the past two decades. However, while the holmium laser is the dominant laser technology in ureteroscopy because it efficiently ablates ... [Biomed. Opt. Express 9, 4552-4568 (2018)]

Abstracts:Automated segmentation of object boundaries or surfaces is crucial for quantitative image analysis in numerous biomedical applications. For example, retinal surfaces in optical coherence tomography (OCT) images play a vital role in the diagnosis and management of retinal diseases. Recently, graph ... [Biomed. Opt. Express 9, 4509-4526 (2018)]

Abstracts:A major obstacle in the monitoring and treatment of neurological diseases is the blood brain barrier (BBB), a semipermeable barrier that prevents the delivery of many therapeutics and imaging contrast agents to the brain. In this work, we explored the possibility of laser-activated perfluorocarbon ... [Biomed. Opt. Express 9, 4527-4538 (2018)]

Abstracts:We propose a novel application of diffuse correlation spectroscopy to evaluate microvascular malfunctions of muscle tissue affected by hyperglycemia and determine their correlation with the severity of diabetic neuropathy at a later stage. Microvascular responses of the thigh muscle and the ... [Biomed. Opt. Express 9, 4539-4551 (2018)]

Abstracts:Visual acuity is dependent on corneal shape and size. A minor variation in surface geometry can cause a deformation of corneal geometry, which affects its optical performance. In this work we demonstrate an algorithm for the simultaneous measurement of corneal tomography and topography with a ... [Biomed. Opt. Express 9, 4443-4458 (2018)]

Abstracts:Lithium-based medications are used successfully to treat many mental disorders, including bipolar disorder and Alzheimer’s disease. However, the therapeutic mechanisms are not well characterized due to limitations in detecting lithium in organs and cells. This limits the ability to improve ... [Biomed. Opt. Express 9, 4459-4471 (2018)]

Abstracts:Photothermal therapy (PTT) has the capability for selective treatment, in which light delivered to the target is converted into heat and subsequently causes coagulative necrosis. However, optical scattering in biological media limits light penetration, thus reducing therapeutic efficacy. Here, we ... [Biomed. Opt. Express 9, 4472-4480 (2018)]

Abstracts:Automatic segmentation of esophageal layers in OCT images is crucial for studying esophageal diseases and computer-assisted diagnosis. This work aims to improve the current techniques to increase the accuracy and robustness for esophageal OCT image segmentation. A two-step edge-enhanced graph ... [Biomed. Opt. Express 9, 4481-4495 (2018)]

Abstracts:A method based on a dual-type (transmission and fluorescence) hyperspectral microscopic image system was developed to identify species of intestinal fungi. Living fungi are difficult to identify via transmission spectra or fluorescence spectra alone. We propose an identification method based on ... [Biomed. Opt. Express 9, 4496-4508 (2018)]