To discover the point of maximum interactive effect, we examined the time sequence of high (above (42.5 degrees C) or low (below 42.5 degrees C) -hyperthermia and cis-diammine dichloroplatinum (II) (CDDP). Simultaneous or post-hyperthermic CDDP (0.5 micrograms/ml) treatment at 43 degrees C resulted in a slight synergistic effect, with thermoenhancement ratios (TER) of 1.42 or 1.38, respectively, and there was a significant increase CDDP uptake after both combinations compared with pre-hyperthermic CDDP treatment. However, at 42 degrees C, the maximal interaction (TER = 8.57) was obtained when KB cells were simultaneously heated with CDDP, there was also a significant increase of CDDP uptake by simultaneous procedures compared with pre or post-hyperthermic CDDP treatment. These results indicate that simultaneous or post-hyperthermic CDDP treatment for high-hyperthermia and simultaneous CDDP treatment for low-hyperthermia are the most effective means of CDDP thermochemotherapy with hyperthermia.

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cddp thermochemotherapy 425 degrees interactive effect ratios lowhyperthermia highhyperthermia dichloroplatinum

T, Ohtsubo H, Saito N, Tanaka I, Noda T, Saito E, Kano,.Effect of heat-drug sequences on thermoenhancement and uptake of cis-DDP in human pharyngeal carcinoma.. 16 (1),297-300.

T, Ohtsubo H, Saito N, Tanaka I, Noda T, Saito E, Kano,"Effect of heat-drug sequences on thermoenhancement and uptake of cis-DDP in human pharyngeal carcinoma." 16

T, Ohtsubo H, Saito N, Tanaka I, Noda T, Saito E, Kano,"Effect of heat-drug sequences on thermoenhancement and uptake of cis-DDP in human pharyngeal carcinoma."