The synthesis of new [1]benzopyrano[3',4':5,6]pyrano[2,3-d]pyrimidines and related heterocycles has been reported. The key intermediate 2-amino-3-cyano-4-methyl-4H,5H-pyrano[3,2-c][1]benzopyran-5-one (3) was obtained in one pot synthesis from the reaction of 4-hydroxycoumarin and acetaldehyde-malononitrile (2). The antimicrobial screening was performed for some of the synthesized compounds.

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synthesis pyrano32c1benzopyran5one pot reaction screening compounds heterocycles

A H, Bedair N A, El-Hady A, El-Latif A H, Fakery A M, El-Agrody,.4-Hydroxycoumarin in heterocyclic synthesis. Part III. Synthesis of some new pyrano[2,3-d]pyrimidine, 2-substitute.. 55 (11-12),708-14.

A H, Bedair N A, El-Hady A, El-Latif A H, Fakery A M, El-Agrody,"4-Hydroxycoumarin in heterocyclic synthesis. Part III. Synthesis of some new pyrano[2,3-d]pyrimidine, 2-substitute." 55

A H, Bedair N A, El-Hady A, El-Latif A H, Fakery A M, El-Agrody,"4-Hydroxycoumarin in heterocyclic synthesis. Part III. Synthesis of some new pyrano[2,3-d]pyrimidine, 2-substitute."