The effect of ketorolac tromethamine, a nonsteroidal anti-inflammatory drug, on normal phagocytosis has been studied. When peritoneal macrophages, taken from mice treated intraperitoneally 4 times daily for 7 days with 2 mg ketorolac per day, were cultured ex vivo or when untreated macrophages were cultured with 1-10 microM of ketorolac in vitro, the number of engulfed Candida albicans was no different from saline-treated or untreated controls. In contrast, macrophages from mice treated intraperitoneally 4 times daily for 7 days with 0.4 mg dexamethasone per day or cultured with 1-10 microM dexamethasone had a greater than or equal to 54% reduction in phagocytosis (p less than 0.001). Thus, ketorolac is a nonsteroidal anti-inflammatory drug which does not inhibit the phagocytic activity of murine mononuclear phagocytes.

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phagocytosis candida phagocytic activity antiinflammatory

E B, Fraser-Smith T R, Matthews,.Effect of ketorolac on phagocytosis of Candida albicans by peritoneal macrophages.. 16 (3),151-5.

E B, Fraser-Smith T R, Matthews,"Effect of ketorolac on phagocytosis of Candida albicans by peritoneal macrophages." 16

E B, Fraser-Smith T R, Matthews,"Effect of ketorolac on phagocytosis of Candida albicans by peritoneal macrophages."