Peroxynitrite (ONOO−), as one type of reactive nitrogen species (RNS), is closely related to multiple pathophysiological processes. Visualization of ONOO− in living system is essential for further study of its physiological functions. However, most existing ONOO− fluorescent probes continuously display the aggregation-caused quenching (ACQ). In present research, a new activatable AIEgen fluorescent probe QM-ONOO− for ONOO− recognition and imaging was proposed. Activation of the probe by ONOO−, induced aggregation of QM−OH. This sensor showed fast response time (<4 min) and high sensitivity (DL, 27.5 nM), large Stock's shift (190 nm), long emission wavelength. Furthermore, the outcomes indicate that QM-ONOO− as an activatable AIEgen fluorescent sensor was robust chemical tool to detect endogenous peroxynitrite in living biological system.

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imaging living biological system detect endogenous peroxynitrite activatable aiegen fluorescent sensor response time aggregationcaused quenching stocks shift visualization of onoo pathophysiological onoo fluorescent probes

Di Zhang, Yong Ye, Yongru Zhang,Xiaojing Han, Zipeng Li, Wenbo Cao, Xiaopeng Yang,.A novel activatable AIEgen fluorescent probe for peroxynitrite detection and its application in EC1 cells. 321 (),128510.

Di Zhang, et al."A novel activatable AIEgen fluorescent probe for peroxynitrite detection and its application in EC1 cells" 321

Di Zhang, Yong Ye, Yongru Zhang,Xiaojing Han, Zipeng Li, Wenbo Cao, Xiaopeng Yang,"A novel activatable AIEgen fluorescent probe for peroxynitrite detection and its application in EC1 cells"