Objectives: The study was undertaken to evaluate cytological changes that occur in the oral mucosa of habitual Pan Masala eaters. Background: The present study was undertaken to find the various morphological changes that occur in the oral mucosa of habitual Pan masala eaters. Methods: Samples from 250 individuals who were eating pan masala for more than 6 months and 250 non-eaters by cotton tipped applicator by scraping the buccal mucosa. Smears were prepared and stained by papanicolou method Atleast 1000 cells were scanned per slide under high power. Result: Total 1,76,530 and 1,26,869 cells were counted in all Test slides and control slides respectively. Statistically high significant difference was found between user and control group. Conclusion: Finding are accumulating regarding the local genotoxic effect such as occurance of micronucleated cells, cells with multiple nuclei, cells with broken egg nuclei, binucleated, and hyperkeratotic cells. These cells were increased according to duration and frequency of pan masala eating. The significance of occurrence of these cells and development of oral cancers requires further studies. Can these parameters be used for early detection of oral cancers? This study might answer this question and may help in reducing the number of oral cancers.

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morphological mucosa smears cytological changes local genotoxic effect micronucleated cells cells early detection of oral cancers papanicolou method masala

P.M. Patil,B.R. Yelikar,.Cytological evaluation of oral mucosa in habitual Pan Masala eaters- A comparative study. 06 (02),.

P.M. Patil,B.R. Yelikar,"Cytological evaluation of oral mucosa in habitual Pan Masala eaters- A comparative study" 06

P.M. Patil,B.R. Yelikar,"Cytological evaluation of oral mucosa in habitual Pan Masala eaters- A comparative study"