Cold plasma is an emerging technology offering many potential applications for regenerative medicine or tissue engineering. This study focused on the characterization of the carboxylic acid functional groups deposited on polymeric substrates using a plasma polymerization process with an acetic acid precursor. The acetic acid precursor contains oxygen and hydrocarbon that, when introduced to a plasma state, forms the polylactide-like film on the substrates. In this study, polymeric substrates were modified by depositing acetic acid plasma film on the surface to improve hydrophilic quality and biocompatibility. The experimental results that of electron spectroscopy for chemical analysis (ESCA) to show for acetic acid film, three peaks corresponding to the C−C group (285.0 eV), C−O group (286.6 eV), and C=O group (288.7 eV) were observed. The resulting of those indicated that appropriate acetic acid plasma treatment could increase the polar components on the surface of substrates to improve the hydrophilicity. In addition, in vitro cell culture studies showed that the embryonic stem (ES) cell adhesion on the acetic acid plasma-treated polymeric substrates is better than the untreated. Such acetic acid film performance makes it become a promising candidate as the surface coating layer on polymeric substrates for biomedical application.

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in vitro cell culture acetic acid plasmatreated polymeric polar components plasma polymerization process surface coating hydrophilicity biomedical application c8722c group polymeric substrates electron spectroscopy chemical analysis polylactidelike film hydrophilic carboxylic acid functional groups embryonic stem es cell adhesion regenerative medicine or tissue engineering

Shu-Chuan Liao,Ko-Shao Chen,Jui-Lung Chien,Su-Chen Chen,Win-Li Lin,.Acetic-Acid Plasma-Polymerization on Polymeric Substrates for Biomedical Application. 9 (7),.

Shu-Chuan Liao,Ko-Shao Chen,Jui-Lung Chien,Su-Chen Chen,Win-Li Lin,"Acetic-Acid Plasma-Polymerization on Polymeric Substrates for Biomedical Application" 9

Shu-Chuan Liao,Ko-Shao Chen,Jui-Lung Chien,Su-Chen Chen,Win-Li Lin,"Acetic-Acid Plasma-Polymerization on Polymeric Substrates for Biomedical Application"