Gold nanocages (AuNCs) are biocompatible and porous nanogold particles that have been widely used in biomedical fields. In this study, hyaluronic acid (HA) and peptide- modified gold nanocages (HA-AuNCs/T/P) loaded with 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide (TPCA-1) were prepared to investigate their potential for combating inflammation. TPCA-1 was released from AuNCs, intracellularly when HA was hydrolyzed by hyaluronidase. HA-AuNCs/T/P show a much higher intracellular uptake than AuNCs/T/P, and exhibit a much higher efficacy on the suppression of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) than free TPCA-1, suggesting great improvement to the anti-inflammatory efficacy of TPCA-1 through the application of AuNCs. HA-AuNCs/T/P can also reduce the production of reactive oxygen species in inflammatory cells. This study suggests that HA-AuNCs/T/P may be potential agents for anti-inflammatory treatment, and are worthy of further investigation.

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tumor necrosis factor alpha antiinflammatory treatment nanogold particles suppression biomedical fields inflammatory cells modified gold nanocages interleukin 6 oxygen 2aminocarbonylamino54fluorophenyl3thiophenecarboxamide

Jingnan Zhao,.Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation. 11 (3),.

Jingnan Zhao,"Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation" 11

Jingnan Zhao,"Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation"