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Nature Communications | Vol.9, Issue.1 | | Pages

BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage

Kajal Biswas,Subha Philip,Aditya Yadav,Betty K. Martin,Sandra Burkett,Vaibhav Singh,Anav Babbar,Susan Lynn North,Suhwan Chang,Shyam K. Sharan

Abstract

Loss of BRCA2 leads to cancer formation. Here, the authors use an insertional mutagenesis approach and identify a multiprotein complex consisting of BRE, USP7 and CDC25A that can support the survival of BRCA2-deficient cells.

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BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage

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Keywords

insertional mutagenesis approach usp7 multiprotein

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Kajal Biswas,Subha Philip,Aditya Yadav,Betty K. Martin,Sandra Burkett,Vaibhav Singh,Anav Babbar,Susan Lynn North,Suhwan Chang,Shyam K. Sharan,.BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage. 9 (1),.

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