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PLoS Neglected Tropical Diseases | Vol.11, Issue.9 | 2017-11-25 | Pages

PLoS Neglected Tropical Diseases

Enhancing case definitions for surveillance of human monkeypox in the Democratic Republic of Congo.

Lynda Osadebe,Robert Shongo Lushima,Joelle Kabamba,Beatrice Nguete,Elisabeth Pukuta,Emile Wemakoy Okitolonda  
Abstract

Human monkeypox (MPX) occurs at appreciable rates in the Democratic Republic of Congo (DRC). Infection with varicella zoster virus (VZV) has a similar presentation to that of MPX, and in areas where MPX is endemic these two illnesses are commonly mistaken. This study evaluated the diagnostic utility of two surveillance case definitions for MPX and specific clinical characteristics associated with laboratory-confirmed MPX cases.Data from a cohort of suspect MPX cases (identified by surveillance over the course of a 42 month period during 2009-2014) from DRC were used; real-time PCR diagnostic test results were used to establish MPX and VZV diagnoses. A total of 333 laboratory-confirmed MPX cases, 383 laboratory-confirmed VZV cases, and 36 cases that were determined to not be either MPX or VZV were included in the analyses. Significant (p

Original Text (This is the original text for your reference.)

Enhancing case definitions for surveillance of human monkeypox in the Democratic Republic of Congo.

Human monkeypox (MPX) occurs at appreciable rates in the Democratic Republic of Congo (DRC). Infection with varicella zoster virus (VZV) has a similar presentation to that of MPX, and in areas where MPX is endemic these two illnesses are commonly mistaken. This study evaluated the diagnostic utility of two surveillance case definitions for MPX and specific clinical characteristics associated with laboratory-confirmed MPX cases.Data from a cohort of suspect MPX cases (identified by surveillance over the course of a 42 month period during 2009-2014) from DRC were used; real-time PCR diagnostic test results were used to establish MPX and VZV diagnoses. A total of 333 laboratory-confirmed MPX cases, 383 laboratory-confirmed VZV cases, and 36 cases that were determined to not be either MPX or VZV were included in the analyses. Significant (p

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Lynda Osadebe,Robert Shongo Lushima,Joelle Kabamba,Beatrice Nguete,Elisabeth Pukuta,Emile Wemakoy Okitolonda,.Enhancing case definitions for surveillance of human monkeypox in the Democratic Republic of Congo.. 11 (9),.

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