Communication between neurons is achieved by rapid signal transduction via highly specialized structural elements known as synaptic contacts. In addition, numerous extrasynaptic mechanisms provide a flexible platform for the local regulation of synaptic signals. For example, peri- and extrasynaptic signaling through the group I metabotropic glutamate receptors (mGluRs) can be involved in the highly compartmentalized regulation of dendritic ion conductances, the induction of input-specific synaptic plasticity, and the local release of retrograde messengers. Therefore, extrasynaptic mechanisms appear to play a key role in the local tuning of dendritic computations. Here, we review recent findings on the role of group I mGluRs in the dendritic signaling of inhibitory interneurons. We propose that group I mGluRs provide a dual-mode signaling device that integrates different patterns of neural activity. By implementing distinct forms of intrinsic and synaptic regulation, group I mGluRs may be responsible for the local fine-tuning of dendritic function.

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neural activity release of retrograde messengers therefore extrasynaptic mechanisms mglurs dualmode signaling device dendritic signaling of inhibitory interneurons induction of inputspecific synaptic plasticity intrinsic and synaptic local tuning of dendritic computations here highly compartmentalized regulation of dendritic ion conductances metabotropic glutamate receptors elements

,.Dendritic signaling in inhibitory interneurons: local tuning via group I metabotropic glutamate receptors. 3 (),.

,"Dendritic signaling in inhibitory interneurons: local tuning via group I metabotropic glutamate receptors" 3

,"Dendritic signaling in inhibitory interneurons: local tuning via group I metabotropic glutamate receptors"