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Evidence-Based Complementary and Alternative Medicine | Vol.2013, Issue. | 2017-05-29 | Pages

Inhibitory Effects of Baicalin on the Expression and Activity of CYP3A Induce the Pharmacokinetic Changes of Midazolam in Rats

Xin Tian,Zhen-Yu Cheng,Han Jin,Jie Gao,Hai-Ling Qiao

Abstract

Baicalin, a flavonoid compound isolated from Scutellaria baicalensis, has been shown to possess antiinflammatory, antiviral, antitumour, and immune regulatory properties. The present study evaluated the potential herb-drug interaction between baicalin and midazolam in rats. Coadministration of a single dose of baicalin (0.225, 0.45, and 0.90 g/kg, i.v.) with midazolam (10 mg/kg, i.v.) in rats resulted in a dose-dependent decrease in clearance (CL) from 25% (P

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Inhibitory Effects of Baicalin on the Expression and Activity of CYP3A Induce the Pharmacokinetic Changes of Midazolam in Rats

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Keywords

herbdrug interaction antiinflammatory antiviral antitumour and immune regulatory properties

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Xin Tian,Zhen-Yu Cheng,Han Jin,Jie Gao,Hai-Ling Qiao,.Inhibitory Effects of Baicalin on the Expression and Activity of CYP3A Induce the Pharmacokinetic Changes of Midazolam in Rats. 2013 (),.

References

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