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Molecules | Vol.13, Issue.6 | 2017-05-30 | Pages

Fractionated Marine Invertebrate Extract Libraries for Drug Discovery

Chris M. Ireland,Tim S. Bugni,Jason Reppart,Malcolm W.B. McCulloch,Mary Kay Harper

Abstract

The high-throughput screening and drug discovery paradigm has necessitated a change in preparation of natural product samples for screening programs. In an attempt to improve the quality of marine natural products samples for screening, several fractionation strategies were investigated. The final method used HP20SS as a solid support to effectively desalt extracts and fractionate the organic components. Additionally, methods to integrate an automated LCMS fractionation approach to shorten discovery time lines have been implemented.

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Fractionated Marine Invertebrate Extract Libraries for Drug Discovery

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Keywords

marine natural products samples fractionation strategies automated lcms fractionation approach screening and drug discovery paradigm discovery time organic components additionally methods

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Chris M. Ireland,Tim S. Bugni,Jason Reppart,Malcolm W.B. McCulloch,Mary Kay Harper,.Fractionated Marine Invertebrate Extract Libraries for Drug Discovery. 13 (6),.

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