Aim: Metabolic syndrome has gained increased attention in the last century after researchers identified its important role in cardiovascular mortality and morbidity in developed countries. Despite limited research into the relationship between metabolic syndrome and prostate cancer (PCa), the precise relationship has not been elucidated due to lack of research into the specific factors associated with PCa. To fill this research gap, we evaluated the incidence of PCa in patients with metabolic syndrome and the relationship between metabolic syndrome and the parameters of PCa. Material and Method: We retrospectively evaluated the biochemical analyses of the serum parameters and pathological reports of 102 PCa patients diagnosed by transrectal ultrasound. After determining the incidence of metabolic syndrome in patients with PCa, we divided the patients into two groups, those with and without a diagnosis of metabolic syndrome. We then compared the serum PSA level, age, total prostate volume, Gleason score, triglyceride (TG) level, high-density lipoprotein cholesterol level (HDL-C), blood pressure, and fasting glucose level of the two groups. Results: We included 102 patients with a diagnosis of prostate cancer in the present study. Among the 102 patients, 18 (17.6%) were diagnosed with metabolic syndrome. While the PSA levels of the PCa patients were found to be significantly lower in those with metabolic syndrome compared to those without metabolic syndrome (P=0.04), no difference was found between the groups regarding the other components of PCa (P>0.05). Discussion: Serum PSA level was found to be significantly lower in those with metabolic syndrome. This result leads us to consider whether prostate biopsy should be performed in patients with metabolic syndrome who have lower PSA levels than the levels currently specified for biopsy. Further research into the parameters of PCa needs to be conducted to confirm our findings.

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pathological reports prostate volume gleason psa triglyceride tg level pca lipoprotein cholesterol

Serkan Bas,.Relationship Between Metabolic Syndrome and Prostate Cancer. 7 (4),.

Serkan Bas,"Relationship Between Metabolic Syndrome and Prostate Cancer" 7

Serkan Bas,"Relationship Between Metabolic Syndrome and Prostate Cancer"