Aims: To study the correlation between dyspnea, radiological findings, and pulmonary function tests (PFTs) in patients with sequelae of pulmonary tuberculosis (TB). Materials and Methods: Clinical history, chest computed tomography (CT), and PFT of patients with post-TB sequelae were recorded. Dyspnea was graded according to the Modified Medical Research Council (mMRC) scale. CT scans were analyzed for fibrosis, cavitation, bronchiectasis, consolidation, nodules, and aspergilloma. Semi-quantitative analysis was done for these abnormalities. Scores were added to obtain a total morphological score (TMS). The lungs were also divided into three zones and scores added to obtain the total lung score (TLS). Spirometry was done for forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and FEV1/FVC. Results: Dyspnea was present in 58/101 patients. A total of 22/58 patients had mMRC Grade 1, and 17/58 patients had Grades 2 and 3 dyspnea each. There was a significant difference in median fibrosis, bronchiectasis, nodules (P < 0.01) scores, TMS, and TLS (P < 0.0001) between dyspnea and nondyspnea groups. Significant correlations were obtained between grades of dyspnea and fibrosis (r = 0.34, P = 0.006), bronchiectasis (r = 0.35, P = 0.004), nodule (r = 0.24, P = 0.016) scores, TMS (r = 0.398, P = 0.000), and TLS (r = 0.35, P = 0.0003). PFTs were impaired in 78/101 (77.2%) patients. Restrictive defect was most common in 39.6% followed by mixed in 34.7%. There was a negative but statistically insignificant trend between PFT and fibrosis, bronchiectasis, nodule scores, TMS, and TLS. However, there were significant differences in median fibrosis, cavitation, and bronchiectasis scores in patients with normal, mild to moderate, and severe respiratory defects. No difference was seen in TMS and TLS according to the severity of the respiratory defect. Conclusion: Both fibrosis and bronchiectasis correlated with dyspnea and with PFT. However, this correlation was not linear. The overall extent of radiological abnormalities correlated only with dyspnea but not with PFT.

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posttb sequelae pft pulmonary function tests forced expiratory volume forced vital capacity nondyspnea fibrosis cavitation bronchiectasis consolidation scores dyspnea radiological findings morphological score respiratory defect tms

Anant Mohan,Raju Sharma,Ashu Seith Bhalla,Ananya Panda,Vishnu Sreenivas,Umasankar Kalaimannan,Ashish Dutt Upadhyay,.Correlation of chest computed tomography findings with dyspnea and lung functions in post-tubercular sequelae. 33 (6),.

Anant Mohan,Raju Sharma,Ashu Seith Bhalla,Ananya Panda,Vishnu Sreenivas,Umasankar Kalaimannan,Ashish Dutt Upadhyay,"Correlation of chest computed tomography findings with dyspnea and lung functions in post-tubercular sequelae" 33

Anant Mohan,Raju Sharma,Ashu Seith Bhalla,Ananya Panda,Vishnu Sreenivas,Umasankar Kalaimannan,Ashish Dutt Upadhyay,"Correlation of chest computed tomography findings with dyspnea and lung functions in post-tubercular sequelae"