MANY drugs enhance or block the actions of adrenaline; but little is known as to whether they act by modifying the metabolism of the catecholamine. In this work the effects of a variety of drugs on the rate of disappearance of radioactive adrenaline in the whole mouse were examined. Details of drug dosage are given in Table 1. Mice were treated with drug and then adrenaline (3 µgm.) labelled with H-3 was administered intravenously. Ten minutes after the adrenaline injection the animals were killed, homogenized in a Waring blendor, and an aliquot of the homogenate assayed for labelled adrenaline remaining1. Control animals, untreated with drug, were given adrenaline labelled with H-3 at a similar time.

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radioactive adrenaline

JUUS AROD ROR OMCHCK,.Activation and Inhibition of Adrenaline Metabolism. 184 (4704),2027.

JUUS AROD ROR OMCHCK,"Activation and Inhibition of Adrenaline Metabolism" 184

JUUS AROD ROR OMCHCK,"Activation and Inhibition of Adrenaline Metabolism"