We suggest a new method to detect amyloidogenic regions in a protein sequence. In the present work it is shown that regions enriched with amino acid residues which have a high expected packing density are responsible for the amyloid formation. Our predictions are consistent with known disease-related amyloidogenic regions for 8 of 11 amyloid-forming proteins and peptides in which positions of amyloidogenic regions have been revealed experimentally.

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expected packing density diseaserelated amyloidogenic regions

O V, Galzitskaia S A, Garbuzinski? M Iu, Lobanov,.[A search for amyloidogenic regions in protein chain].. 40 (5),910-8.

O V, Galzitskaia S A, Garbuzinski? M Iu, Lobanov,"[A search for amyloidogenic regions in protein chain]." 40

O V, Galzitskaia S A, Garbuzinski? M Iu, Lobanov,"[A search for amyloidogenic regions in protein chain]."