A variable energy proton accelerator was commissioned at Fermi National Accelerator Laboratory for use in cancer treatment at the Loma Linda University Medical Center. The advantages of precise dose localization by proton therapy, while sparing nearby healthy tissue, are well documented [R. R. Wilson, Radiology 47, 487 (1946); M. Wagner, Med. Phys. 9, 749 (1982); M. Goitein and F. Chen, Med. Phys. 10, 831 (1983)]. One of the components of the proton therapy facility is a beam delivery system capable of delivering precise dose distributions to the target volume in the patient. To this end, a prototype beam delivery system was tested during the accelerator's commissioning period. The beam delivery system consisted of a beam spreading device to produce a large, uniform field, a range modulator to generate a spread out Bragg peak (SOBP), and various beam detectors to measure intensity, beam centering, and dose distributions. The beam delivery system provided a uniform proton dose distribution in a cylindrical volume of 20-cm-diam area and 9-cm depth. The dose variations throughout the target volume were found to be less than +/- 5%. Modifications in the range modulator should reduce this considerably. The central axis dose rate in the region of the SOBP was found to be 0.4 cGy/spill with an incident beam intensity of 6.7 x 10(9) protons/spill. With an accelerator repetition rate of 30 spills/min and expected intensity of 2.5 x 10(10) protons/spill for patient treatment, this system can provide 50 cGy/min for a 20-cm-diam field and 9-cm range modulation.(ABSTRACT TRUNCATED AT 250 WORDS)

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cancer treatment dose distributions uniform proton dose distribution therapy facility range modulator beam delivery system central axis dose rate spread out bragg peak 20cmdiam field accelerator repetition rate intensity beam centering beam spreading device large uniform variable wilson radiology 47 487 1946 m wagner med phys 9 749 1982 m goitein and f chen med phys 10

G, Coutrakon M, Bauman D, Lesyna D, Miller J, Nusbaum J, Slater J, Johanning J, Miranda P M, DeLuca J, Siebers,.A prototype beam delivery system for the proton medical accelerator at Loma Linda.. 18 (6),1093-9.

G, Coutrakon M, Bauman D, Lesyna D, Miller J, Nusbaum J, Slater J, Johanning J, Miranda P M, DeLuca J, Siebers,"A prototype beam delivery system for the proton medical accelerator at Loma Linda." 18

G, Coutrakon M, Bauman D, Lesyna D, Miller J, Nusbaum J, Slater J, Johanning J, Miranda P M, DeLuca J, Siebers,"A prototype beam delivery system for the proton medical accelerator at Loma Linda."