Complete and unambiguous assignments of the 1H- and 13C-nmr spectra of the potent antitumor antibiotic staurosporine have been accomplished using a combination of one- and two-dimensional nmr techniques, including one-bond and long-range heteronuclear multiple-quantum coherence spectroscopy (HMQC). Staurosporine was found to be highly cytotoxic in the KB and P-388 assays but was inactive in the microtubulin assembly assay.

+More

1h and 13cnmr spectra longrange heteronuclear multiplequantum coherence spectroscopy onebond p388 antibiotic staurosporine one and twodimensional nmr techniques

D, Meksuriyen G A, Cordell,.Biosynthesis of staurosporine, 1. 1H- and 13C-NMR assignments.. 51 (5),884-92.

D, Meksuriyen G A, Cordell,"Biosynthesis of staurosporine, 1. 1H- and 13C-NMR assignments." 51

D, Meksuriyen G A, Cordell,"Biosynthesis of staurosporine, 1. 1H- and 13C-NMR assignments."