The bacterial mutagenicity (Ames test) and the one-electron reduction potential for several nitropyridines, nitropyrazines and nitropyrimidines were determined. It was found that, although these nitroheterocycles underwent one-electron reduction more easily than metronidazole, they were not mutagenic in the Ames test. Six-membered ring nitroheterocycles, will, in general, exhibit diminished mutagenic potential compared to five-membered ring nitroheterocycles, and it is postulated that this effect is due to differences in the electronic nature and potential chemical reactivity of their respective nitrenium ions.

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potential chemical reactivity bacterial mutagenicity ames test fivemembered oneelectron reduction potential nitrenium ions electronic nature

G D, Hartman R D, Hartman,.Non-mutagenic nitroheterocycles. The lack of correlation between bacterial mutagenicity and one-electron reduction potential.. 117 (3-4),271-7.

G D, Hartman R D, Hartman,"Non-mutagenic nitroheterocycles. The lack of correlation between bacterial mutagenicity and one-electron reduction potential." 117

G D, Hartman R D, Hartman,"Non-mutagenic nitroheterocycles. The lack of correlation between bacterial mutagenicity and one-electron reduction potential."