We report the case of a 78-year-old man who presented with acute myeloid leukaemia showing subpopulations of cells expressing platelet-associated markers and the presence of a pan-myeloid component, besides glycophorin A-positive cells. Most of the immature cells had a proerythroblast-like morphology and we classified this case as an FAB-M6 variant, as suggested by Bain (1). According to the WHO classification, this leukaemia fulfilled the criteria of'AML with multilineage dysplasia' (2). Immunophenotyping characteristics showed two distinct aberrant subpopulations, a young pan-myeloid (CD45+ with low density, CD34+, CD117+, CD13+, CD33+, partial cytoplasmic myeloperoxidase (MPO)+) population with platelet-associated markers (CD41+, CD42+, CD61+) and a CD45+, CD117+, CD34- population with partial CD235a positivity indicative for erythroid maturation. This case belongs to the group of 'early' erythroblastic leukaemias where a subset of progenitor cells present with erythroid-megakaryocyte bipotentiality or are blocked at an early BFU-E (burst-forming unit erythrocyte)-like stage of erythroid differentiation (11, 12, 13).

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cd235a positivity erythroid glycophorin cytoplasmic myeloperoxidase mpo plateletassociated markers panmyeloid component proerythroblastlike morphology erythroidmegakaryocyte bipotentiality density cd34 cd117 cd13 early erythroblastic

L, Dani?ls K, Guerti K, Vermeulen H, De Raeve E, Van Assche A L, Van de Velde Z N, Berneman M, Van Der Planken,.Acute myeloid leukaemia of mixed megakaryocytic and erythroid origin: a case report and review of the literature.. 62 (5),308-14.

L, Dani?ls K, Guerti K, Vermeulen H, De Raeve E, Van Assche A L, Van de Velde Z N, Berneman M, Van Der Planken,"Acute myeloid leukaemia of mixed megakaryocytic and erythroid origin: a case report and review of the literature." 62

L, Dani?ls K, Guerti K, Vermeulen H, De Raeve E, Van Assche A L, Van de Velde Z N, Berneman M, Van Der Planken,"Acute myeloid leukaemia of mixed megakaryocytic and erythroid origin: a case report and review of the literature."