Transcytosis of macromolecules through lung endothelial cells is the primary route of transport from the vascular compartment into the interstitial space. Endothelial transcytosis is mostly a caveolae-dependent process that combines receptor-mediated endocytosis, vesicle trafficking via actin-cytoskeletal remodeling, and SNARE protein directed vesicle fusion and exocytosis. Herein, we review the current literature on caveolae-mediated endocytosis, the role of actin cytoskeleton in caveolae stabilization at the plasma membrane, actin remodeling during vesicle trafficking, and exocytosis of caveolar vesicles. Next, we provide a concise summary of experimental methods employed to assess transcytosis. Finally, we review evidence that transcytosis contributes to the pathogenesis of acute lung injury. © 2020 American Physiological Society. Compr Physiol 10:491-508, 2020.

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actincytoskeletal remodeling acute lung exocytosis actin cytoskeleton caveolae stabilization receptormediated endocytosis vesicle trafficking vesicle trafficking and exocytosis of caveolar vesicles caveolaemediated snare protein directed vesicle fusion endothelial transcytosis

Minshall, Richard D,Jones, Joshua H,.Lung Endothelial Transcytosis. 10 (2),.

Minshall, Richard D,Jones, Joshua H,"Lung Endothelial Transcytosis" 10

Minshall, Richard D,Jones, Joshua H,"Lung Endothelial Transcytosis"