The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.

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innate and adaptive immune responses respiratory disease sarscov2 infection

Suprun, Maria, Alexandropoulos, Konstantina, Charap, Andrew,Vabret, Nicolas, Fernandez, Nicolas, Gümüş, Zeynep H., Moon, Chang, Casanova-Acebes, Maria, Hegde, Samarth, Homann, Dirk, Horowitz, Amir, Ruan, Dan Fu, Lindblad, Katherine, Mahmood, Zafar, Reyes Torres, Ivan, Laserson, Uri, Bogunovic, Dusan, Tran, Michelle, Belabed, Meriem, Cody, Evan, Risson, Emma, Schanoski, Alessandra Soares, Kim, Joel, Lin, Matthew, Wilk, C. Matthias, van der Heide, Verena, Lozano-Ojalvo, Daniel, Meritt, Elliot, Cho, Judy, Roberto, Mark, Grasset, Emilie, Brown, Matthew, Spindler, Matthew P., Moreira, Alvaro, Lubitz, Gabrielle, Magen, Assaf, Merad, Miriam, Dalla, Erica, Plitt, Tamar, Mateus-Tique, Jaime, Kenigsberg, Ephraim, Pothula, Venu, Heeger, Peter, Gruber, Conor, Tan, Jessica, Aleynick, Mark, Chan, Andrew, Gregory, Jill K., Aguirre-Ghiso, Julio, Levantovsky, Rachel, Malle, Louise, Grout, John, Bozkus, Cansu Cimen, Vaninov, Natalie, Kodysh, Julia, Salomé, Bérengère, Bhardwaj, Nina, Park, Matthew D., Chen, Steven T., Esai Selvan, Myvizhi, Britton, Graham J., Cossarini, Francesca, Shang, Joan, Brown, Brian D., Faith, Jeremiah, Centa, Monica, Saffern, Miriam, Greenbaum, Benjamin, Catalan, Jovani, Jha, Divya, Kamphorst, Alice O., Agrawal, Manasi, Redes, Jamie, Sanchez-Paulete, Alfonso R., Hamon, Pauline, Humblin, Etienne, Martinez-Delgado, Gustavo, Noel, Justine, Mehandru, Saurabh, Kuksin, Maria, Samstein, Robert M., Krammer, Florian, Leader, Andrew, Pia, Luisanna, Chung, Jonathan, Curotto de Lafaille, Maria A., O’Donnell, Tim, Ota, Miyo,.Immunology of COVID-19: current state of the science. 52 (6),.

Suprun, Maria, et al."Immunology of COVID-19: current state of the science" 52

Suprun, Maria, Alexandropoulos, Konstantina, Charap, Andrew,Vabret, Nicolas, Fernandez, Nicolas, Gümüş, Zeynep H., Moon, Chang, Casanova-Acebes, Maria, Hegde, Samarth, Homann, Dirk, Horowitz, Amir, Ruan, Dan Fu, Lindblad, Katherine, Mahmood, Zafar, Reyes Torres, Ivan, Laserson, Uri, Bogunovic, Dusan, Tran, Michelle, Belabed, Meriem, Cody, Evan, Risson, Emma, Schanoski, Alessandra Soares, Kim, Joel, Lin, Matthew, Wilk, C. Matthias, van der Heide, Verena, Lozano-Ojalvo, Daniel, Meritt, Elliot, Cho, Judy, Roberto, Mark, Grasset, Emilie, Brown, Matthew, Spindler, Matthew P., Moreira, Alvaro, Lubitz, Gabrielle, Magen, Assaf, Merad, Miriam, Dalla, Erica, Plitt, Tamar, Mateus-Tique, Jaime, Kenigsberg, Ephraim, Pothula, Venu, Heeger, Peter, Gruber, Conor, Tan, Jessica, Aleynick, Mark, Chan, Andrew, Gregory, Jill K., Aguirre-Ghiso, Julio, Levantovsky, Rachel, Malle, Louise, Grout, John, Bozkus, Cansu Cimen, Vaninov, Natalie, Kodysh, Julia, Salomé, Bérengère, Bhardwaj, Nina, Park, Matthew D., Chen, Steven T., Esai Selvan, Myvizhi, Britton, Graham J., Cossarini, Francesca, Shang, Joan, Brown, Brian D., Faith, Jeremiah, Centa, Monica, Saffern, Miriam, Greenbaum, Benjamin, Catalan, Jovani, Jha, Divya, Kamphorst, Alice O., Agrawal, Manasi, Redes, Jamie, Sanchez-Paulete, Alfonso R., Hamon, Pauline, Humblin, Etienne, Martinez-Delgado, Gustavo, Noel, Justine, Mehandru, Saurabh, Kuksin, Maria, Samstein, Robert M., Krammer, Florian, Leader, Andrew, Pia, Luisanna, Chung, Jonathan, Curotto de Lafaille, Maria A., O’Donnell, Tim, Ota, Miyo,"Immunology of COVID-19: current state of the science"