Abstract A small interfering RNA (siRNA) inhibitors have demonstrated the novel modality for suppressing infectious diseases. Sixty-one siRNA molecules, predicted by the bioinformatics programs, were screened for the possibility of treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using an in vitro plaque assay. Among six siRNA leads with the efficacy of reducing plaque number, the siRNA targeting RNA-dependent RNA polymerase (RdRp) showed a reduction in SARS-CoV-2 infection-induced fever and virus titer in the Golden Syrian hamster and rhesus macaque. These results suggest the potential for RdRp targeting siRNA as a new treatment for the coronavirus disease 2019 (COVID-19).

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virus acute respiratory syndrome small interfering rna sirna inhibitors rdrp targeting sirna infectious coronavirus disease 2019 plaque rnadependent rna polymerase rdrp sarscov2 infectioninduced fever

Jeong, Seong Tae, Kim, Na Young, Song, Dong Hyun, Song, Youngjo,Gu, Hun, Sim, Euni, Shin, Young Kee, Yu, Chi Ho, Choi, Jun Young, Hur, Gyeung Haeng,.A Small interfering RNA lead targeting RNA-dependent RNA-polymerase effectively inhibit the SARS-CoV-2 infection in Golden Syrian hamster and Rhesus macaque. (),.

Jeong, Seong Tae, et al."A Small interfering RNA lead targeting RNA-dependent RNA-polymerase effectively inhibit the SARS-CoV-2 infection in Golden Syrian hamster and Rhesus macaque"

Jeong, Seong Tae, Kim, Na Young, Song, Dong Hyun, Song, Youngjo,Gu, Hun, Sim, Euni, Shin, Young Kee, Yu, Chi Ho, Choi, Jun Young, Hur, Gyeung Haeng,"A Small interfering RNA lead targeting RNA-dependent RNA-polymerase effectively inhibit the SARS-CoV-2 infection in Golden Syrian hamster and Rhesus macaque"