BACKGROUND The prognostic value of high-sensitivity troponin T (hs-TnT) elevation after elective percutaneous coronary intervention (PCI) in patients with or without raised baseline hs-TnT levels is unclear. ;OBJECTIVES The goal of this study was to assess whether the prognostic value of post-procedural hs-TnT level after elective PCI depends on the baseline hs-TnT level. ;METHODS This study included 5,626 patients undergoing elective PCI who had baseline and peak post-procedural hs-TnT measurements available. The primary outcome was 3-year mortality (with risk estimates calculated per SD increase of the log hs-TnT scale). ;RESULTS Patients were divided into 4 groups: nonelevated baseline and post-procedural hs-TnT levels (hs-TnT <= 0.014 mu g/l; n = 742); nonelevated baseline but elevated post-procedural hs-TnT levels (peak post-procedural hs-TnT > 0.014 mu g/l; n = 2,721); elevated baseline hs-TnT levels (hs-TnT > 0.014 mu g/l) with no further rise post-procedure (n = 516); and elevated baseline hs-TnT levels with a further rise post-procedure (n = 1,647). A total of 265 deaths occurred: 6 (1.6%) in patients with nonelevated baseline and post-procedural hs-TnT levels; 54 (3.8%) in patients with nonelevated baseline but elevated post-procedural hs-TnT levels; 50 (16.0%) in patients with elevated baseline hs-TnT levels with no further rise post-procedure; and 155 (18.2%) in patients with elevated baseline hs-TnT levels with a further rise post-procedure (p < 0.001). After adjustment, baseline hs-TnT levels (hazard ratio [HR]: 1.22; 95% confidence interval [CI]: 1.09 to 1.38; p < 0.001) but not peak post-procedural hs-TnT levels (HR: 1.04; 95% CI: 0.85 to 1.28; p = 0.679) were associated with an increased risk of mortality. Peak post-procedural hs-TnT findings were not associated with mortality in patients with nonelevated (HR: 0.93; 95% CI: 0.69 to 1.25; p = 0.653) or elevated (HR: 1.24; 95% CI: 0.91 to 1.69; p= 0.165) baseline hs-TnT levels. ;CONCLUSIONS In patients with coronary artery disease undergoing elective PCI, an increase in post-procedural hs-TnT level did not offer prognostic information beyond that provided by the baseline level of the biomarker. (C) 2016 by the American College of Cardiology Foundation.

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hr 124 95 mu baseline and peak postprocedural hstnt measurements the log hstnt scale level of the biomarker highsensitivity troponin t hstnt elevation

Ndrepepa, G ,Cassese, S ,Braun, S ,Laugwitz, KL ,Fusaro, M ,Kastrati, A,Schunkert, H ,Husser, O ,Hengstenberg, C ,Byrne, RA ,Colleran, R ,Kufner, S ,Ott, I ,Hieber, J ,.High-Sensitivity Troponin T and Mortality After Elective Percutaneous Coronary Intervention. 68 (),10.

Ndrepepa, G , et al."High-Sensitivity Troponin T and Mortality After Elective Percutaneous Coronary Intervention" 68

Ndrepepa, G ,Cassese, S ,Braun, S ,Laugwitz, KL ,Fusaro, M ,Kastrati, A,Schunkert, H ,Husser, O ,Hengstenberg, C ,Byrne, RA ,Colleran, R ,Kufner, S ,Ott, I ,Hieber, J ,"High-Sensitivity Troponin T and Mortality After Elective Percutaneous Coronary Intervention"