We assessed the performance of syndromic indicators based on Google Flu Trends (GFT) and emergency department (ED) data for the early detection and monitoring of the 2009 H1N1 pandemic waves in Manitoba.Time-series curves for the weekly counts of laboratory-confirmed H1N1 cases in Manitoba during the 2009 pandemic were plotted against the three syndromic indicators: 1) GFT data, based on flu-related Internet search queries, 2) weekly count of all ED visits triaged as influenza-like illness (ED ILI volume), and 3) percentage of all ED visits that were triaged as an ILI (ED ILI percent). A linear regression model was fitted separately for each indicator and correlations with weekly virologic data were calculated for different lag periods for each pandemic wave.All three indicators peaked 1-2 weeks earlier than the epidemic curve of laboratory-confirmed cases. For GFT data, the best-fitting model had about a 2-week lag period in relation to the epidemic curve. Similarly, the best-fitting models for both ED indicators were observed for a time lag of 1-2 weeks. All three indicators performed better as predictors of the virologic time trends during the second wave as compared to the first. There was strong congruence between the time series of the GFT and both the ED ILI volume and the ED ILI percent indicators.During an influenza season characterized by high levels of disease activity, GFT and ED indicators provided a good indication of weekly counts of laboratory-confirmed influenza cases in Manitoba 1-2 weeks in advance.

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virologic time trends weekly virologic data influenzalike illness ed ili laboratoryconfirmed influenza weekly counts of laboratoryconfirmed h1n1 cases in manitoba early detection and monitoring of the internet search disease indicators epidemic curve of laboratoryconfirmed linear regression model gft h1n1 pandemic waves bestfitting models google flu trends gft and emergency department ed data

Mohammad Tufail, Malik Abba, Gumel Laura H, Thompson Trevor, Strome Salaheddin M, Mahmud,."Google flu trends" and emergency department triage data predicted the 2009 pandemic H1N1 waves in Manitoba.. 102 (4),294-7.

Mohammad Tufail, Malik Abba, Gumel Laura H, Thompson Trevor, Strome Salaheddin M, Mahmud,""Google flu trends" and emergency department triage data predicted the 2009 pandemic H1N1 waves in Manitoba." 102

Mohammad Tufail, Malik Abba, Gumel Laura H, Thompson Trevor, Strome Salaheddin M, Mahmud,""Google flu trends" and emergency department triage data predicted the 2009 pandemic H1N1 waves in Manitoba."