Affiliation:The ministry of health ZheYi big affiliated hospital infectious diseases key laboratory of infectious diseases Zhejiang province health department Zhejiang medical university The infectious diseases and parasitic diseases to the artificial liver group The ministry of health of influenza a (H1N1) clinical expert group Editor in chief Zhejiang university The Chinese academy of engineering Zhejiang province center for disease control and prevention The Chinese medical association Huashan hospital of fudan university
Subject:Infectious diseases and infectious diseases   
Introduction:

Professor Li has initiated a special and effective Artificial Liver Supporting System (ALSS) in treating severe hepatitis, which is a breakthrough and has significantly decreased the mortality, and provides a new way in treating liver failure as well. Determined to tackle the difficulty worldwide in treating severe hepatitis, the mortality of which may reach 80%, ever since 1986, Professor Li has spent 20 years in the field and created a special and effective ALSS in treating severe hepatitis. In order to spread the new way of ALSS to the whole country, she has presided and finished 8 national continuous education programs. She was elected as chairman in the first, second and third International & National Symposium of Artificial liver. As chief author, She published artificial liver book, which is basing on her decades of experiences of treating severe hepatitis, and the book is the first one of the field of ALSS in China. To promote the study on artificial liver in the country, professor Li organized the Group for Artificial Liver Science to make guidelines for standardizing clinical application of ALSS. Her study on artificial liver was funded both by the 15th Key Technology R&D Program of national High-tech Research & Development 863 Program and National Natural Science Foundation.
She firstly highlighted the theory of infectious microecology, which helps to clarify the profile of changes in gut flora of patients with liver diseases. Base on the theory, some new Ag of gut bacterium were discovered.

Her group has done a series of investigations on effects of changes in gut flora on the liver function in patients with chronic hepatitis and chronic severe hepatitis. As a chief author, the book INFECTIOUS MICROECOLOGY was published in China in 2002. The program of relationship between changes in gut flora and the chronic graft dyfunction (CGD) was granted by national basic research fund(called 973 program). She and her group discovered 5 new genetypes of ESBLs, then the news was enrolled in GenBank. Her group set up a new conveniently phenotype screening method to detect AmpC enzyme, and firstly used gene expression method in studing ESBLs. A new gene expressed system of ESBLs was build by the group for the further gene functional research.