Battling the COVID-19 pandemic and preparing for the inevitable next surge requires a data-driven population health approach. A special issue of the peer-reviewed journal Population Health Management is dedicated to combatting COVID-19. It embraces systems thinking and key insights from other industries.

Point-of-view, original research, and two roundtable articles comprise the special issue. Included in the issue are the following articles:

• If Aviation Were in Control of the COVID-19 Response
• A Simple Algorithm for Return to Workplace Employer Antibody Testing
• Health Inequalities in the Use of Telehealth in the United States in the Lens of COVID-19
• We Know Health Is Not Elective: Impacts of COVID-19
• Changes in Health Care Following COVID-19